Turmacin® and it’s development

Along with its rich history of use, turmeric’s scientific portfolio is also rich in evidence in its use particularly for managing inflammation and supporting joint health. Joint health is one of the top concerns among adults globally, as the fear of losing mobility to aggressively worsening osteoarthritis is common.

Turmacin® is an innovative clinically researched ingredient that brings the joint and cartilage health benefits of turmeric to dietary supplements. Featuring water-soluble TurmerosaccharidesTM, our patented, bioactive polysaccharide, Turmacin® is the clean label, natural way to add joint and cartilage support functionality to your formulation.

As there is a bevy of turmeric extracts that focus on the content of standardized curcuminoids, the opportunity to develop an effective and safe extract that focuses on the power of its unique polysaccharides has proven worthy.

Traditional uses

Turmeric has a very long history of culinary, cosmetic, and medicinal use. Throughout Asia and India, there is substantial use of turmeric in traditional medical modalities to fight inflammation and pain.

In Ayurveda practices, turmeric is well-documented to have several useful actions for the treatment of rheumatism, sprains/swelling, and other conditions characterized by inflammation. Ayurvedic texts include dosage forms such as svarasa (juice), kalka (bolus/paste), kvatha (decoction), hima (cold infusion), phaṇṭa (hot infusion), and curna (powder).

In Indian culture, turmeric is held in high esteem beyond just for healing purposes. Hindus hold the herb sacred and it is part of a wedding tradition where the groom ties mangala sutra, a string dyed yellow from turmeric around the bride’s neck in a loving, symbolic gesture. And in South India, men and women who want to protect themselves from evil spirits will wear a turmeric rhizome piece as an amulet.

Water-soluble and oil-soluble
components of turmeric

The vast majority of research on turmeric-based products has been conducted on:

  • Whole turmeric powder
  • Volatile oil portions of turmeric
  • Isolated curcuminoid extracts (especially curcumin)

Meanwhile, over 90% of the remaining water-soluble constituents of turmeric have been neglected and rarely investigated for their own health benefits. That begs the question: what have we been throwing away?

At Natural Remedies, we were on a quest to discover these unexplored components of turmeric. After years and years of research by our team of herbalists and scientists, we discovered that turmeric also contains a special class of water-soluble polysaccharides that are potent, promising, and bioactive. We named them Turmerosaccharides.

Turmacin® is backed by 5 clinical studies:

Clinical Study 1

Turmacin® effectively managed the symptoms of knee osteoarthritis and supported physical function of knee joints.

Clinical Study 2

Turmacin® (0.5g and 1g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants.

Clinical Study 3

Compared to placebo, the Turmacin®/ curcuminoids combination significantly improves knee pain and function among people with inflammatory knee osteoarthritis.

Clinical Study 4

B-Turmactive and BY reduced self-reported, mild/moderate joint pain after 3 days and 1 week of treatment. The analgesic effect of B-Turmactive was progressive and accompanied by an objective decrease in inflammatory status.

Clinical Study 5

Turmacin® an extract of Curcuma longa containing Turmerosaccharides was found to be safe and tolerable at both the tested doses administered for the given duration of trial period in healthy adult volunteers.

Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial

Condition

Subjects with primary knee osteoarthritis

Dose

500 mg twice a day

Participants

30 subjects per group (Age: ≥ 40 years)

Duration

42 days

Evaluation

On day 21 and day 42 using WOMAC, VAS, and CGIC scales

Outcome

Turmacin® effectively managed the symptoms of knee osteoarthritis and supported physical function of knee joints

Madhu et al. Inflammopharmacology 2013, 21(2): 129-136.

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Effect of Turmacin® supplementation on joint discomfort and functional outcome among healthy participants: A randomized placebo-controlled trial

Condition

Healthy volunteers

Dose

0.5 g and 1 g

Participants

90 subjects

Duration

84 days

Evaluation

Valuation of pain at days 1, 5, 7, 28, 56, and 84 for VAS; Time to onset of pain; Range of Motion using Electrogoniometry, Joint function and force assessment using Isokinetic dynamometry

Outcome

Turmacin® (0.5g and 1g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants

Jeffrey Pradeep Raj et al, Complementary Therapies in Medicine 53 (2020) 102522

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Clinical Evidence for Turmacin® – A randomised placebo controlled study in Australia

Condition

Subjects with knee osteoarthritis, and the presence of a moderate amount of effusion-synovitis

Dose

800 mg Turmacin® plus 200 mg curcuminoids

Participants

70 subjects

Duration

12 weeks

Evaluation

Knee MRI scans and their knee pain was calculated using the VAS scale. Also, OARSI-OMERACT was used.

Outcome

Compared to placebo, the Turmacin®/ curcuminoids combination significantly improves knee pain and function among people with inflammatory knee osteoarthritis.

Wang Z et al., Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Ann Intern Med. 2020 Sep 15. doi: 10.7326/M20-0990.

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Clinical Evidence for Turmacin® – A Randomised, Parallel and Double Blind study in Spain

Condition

Mild and Moderate Knee Pain on Healthy Volunteers

Dose

New formulation of water-soluble Turmeric extracts 500 mg and insoluble curcuminoids (B-Turmactive) 19.5 mg or brewer’s yeast as a placebo for 1 week

Outcome

B-Turmactive and BY reduced self-reported, mild/moderate joint pain after 3 days and 1 week of treatment. The analgesic effect of B-Turmactive was progressive and accompanied by an objective decrease in inflammatory status.

Participants

68 subjects

Duration

1 weeks

Evaluation

Primary: WOMAC pain subscale on day 1; day 3; day 7. Visual analogue scale of 5 items derived from 24 items WOMAC scale

Secondary: Anthropometric data; Biochemistry for on-going study control; Biochemistry for on-going study control.

Lorena Calderón-Pérez et al, Journal of Medicinal Food, http://doi.org/10.1089/jmf.2020.0074

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Safety Clinical Evidence for Turmacin® – A randomised open label clinical study in healthy volunteers

Condition

Healthy subjects

Dose

1000 or 2000 mg of Turmacin® an extract of Curcuma longa

Participants

48 subjects (24 each arm)

Duration

84 days

Evaluation

Haematological, biochemical, and urinalysis parameters) were assessed at baseline, day 42 and 84 as primary endpoint. The secondary end point was change in the vital signs, electrocardiogram (ECG) from baseline on day 42 and 84

Outcome

Turmacin® an extract of Curcuma longa containing Turmerosaccharides was found to be safe and tolerable at both the tested doses (till 2g) administered for the given duration of trial period in healthy adult volunteers.

Selvi et al.Safety of NR-INF-02, an Extract of Curcuma long containing turmerosaccharides, in healthy volunteers: A Randomized, Open-label Clinical Trial. Alternative Therapies in Health and Medicine 2020 Aug 20; AT6360. Online ahead of print.

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Pre-Clinical Evidence: Effect on Inflammation and Pain Severity

Outcomes of the study

Reference: Sasikumar et al. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2017, 16, 193-202

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Turmacin® reduced pain severity by 50%
in 3 hours & the effect was maintained till 24 hours

Turmacin® has multiple modes of action

Turmacin® supports joint health by maintaining equilibrium
between degradation and synthesis of cartilage matrix

Reduces production of:

  • Inflammatory mediators
  • Reactive oxygen species
  • Aging

Increases synthesis of:

  • Collagen synthesis
  • TProteoglycan synthesis
  • Anti-inflammatory cytokines
Health Benefit:
Supports Joint Health*

Dosage:
500 mg – 1000 mg per day

Turmacin®: Stands for the things that matter to you

Formulations possible with Turmacin®

Applications of Turmacin®

Turmacin®: Sustainably making a difference at every step

The process of cultivating Curcuma longa for Turmacin® has always been one that keeps renewability of resources – including human – at the forefront to sustain quality yields.

We minimize our carbon footprint by cultivating mostly with non-fossil fuels and without machinery that uses the fossil fuels. We reuse the water used for growing the botanical crop. During manufacturing/processing,

the majority of the power utilized is from hydro and solar energy sources. All the effluents from manufacturing facility are disposed responsibly as per statutory norms. We are an ISO14001-certified (environmental management) organization, and our manufacturing facility is surrounded by trees to provide a green belt.

Turmacin® is manufactured under strict global guidelines of safety and quality control. Its manufacturer, Natural Remedies, has achieved ISO 22000, ISO 9001and OHSAS 18001 certification from Bureau Veritas, is NSF GMP-certified, USFDA inspected.

Why choose Turmacin®?

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