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  • Clinical Research
  • Mechanisms of Action
  • Dosage
  • Application of GutGard®
  • Why Choose GutGard®?
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GutGard® and it’s development gutgard and it’s development

GutGard® and it’s development

Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. Poor digestion leads to lack of energy, poor sleep, and overall malaise. 

GutGard® goes beyond deglycyrrhization, as conventional DGL extracts lack bioactive flavonoids found in the root. GutGard® is extracted using a unique extraction process that retrieves the bioactive flavonoid profile. It is standardized to contain 10% total flavonoids no more than 0.5% glycyrrhizin. And the key difference between GutGard® and DGL extract is that DGL extracts typically contain negligible amounts of flavonoids – in fact, DGL is a product obtained following the removal of glycyrrhizin and is not standardized to any biologically active constituents. GutGard® is closer to nature than DGL as acids are not used in its production process, whereas DGL production involves treatment with acids/alkali.

GutGard® for daily digestive health
gutgard and it’s development gutgard and it’s development gutgard and it’s development

GutGard® for daily digestive health

GutGard is a clinically tested nutraceutical ingredient that reduces gastro intestinal irritation and discomfort. GutGard is derived from the natural Glycyrrhiza glabra(liquorice) plant and contains high levels of glabridin.

GutGard® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard® by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.

Effectively BK

GutGard® works for you by effectively

Eliminating heartburn & regurgitation along with improving general digestive health

Vomitting Nausea Upper abdominal fullness & pain Heartburn/regurgitationafter meals Loss of appetite Bloating Belching Pain inswallowing Heartburn while lying/ standing Early satiety

Early satiety

Early satiety

Upper abdominal fullness & pain

Upper abdominal fullness & pain

Heartburn/regurgitation after meals

Heartburn/regurgitation after meals

Nausea

Nausea

Heartburn while lying/ standing

Heartburn while lying/ standing

Loss of appetite

Loss of appetite

Pain in swallowing

Pain in swallowing

Vomitting

Vomitting

Belching

Belching

Bloating

Bloating

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GutGard®: Backed by human clinical
studies for daily digestive health

gutgard and it’s development

Clinical Study 1

GutGard® showed 88% reduction in the total symptoms score to effectively eliminate heartburn & regurgitation By day 28, 87% reduction in the frequency of heartburn and 72% reduction in the severity of heartburn was assessed

Clinical Study 2

GutGard® significantly lowers the symptoms of daily digestive health problems (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life

Clinical Study 3

48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT

Randomized double-blind, placebo-controlled clinical study in Subjects with Gastro-Esophageal Reflux (GER) Related Symptoms - Heartburn & Regurgitation

Condition

Condition

Subjects with Heartburn & Regurgitation - Gastro-Esophageal Reflux(GER) Related Symptoms

Participants

Participants

200 subjects (Age: 18-60 years)

Dose

Dose

75 mg twice a day before food

Duration

Duration

28 days

Evaluation

Evaluation

On day 0, 7, 14 and day 28 & 7-days post treatment for rebound effect

Outcome

Outcome

GutGard® effectively eliminated the symptoms of Gastro-Esophageal Reflux (GER) (heartburn and regurgitation)

Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012, Article ID 216970, 9 pages, 2012.

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Randomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.

Condition

Condition

Subjects with functional dyspepsia

Participants

Participants

50 subjects (Age: 18-65 years)

Dose

Dose

75 mg, two times a day after food

Duration

Duration

30 days

Evaluation

Evaluation

On day 15 and day 30

Outcome

Outcome

GutGard® effectively managed the symptoms read more of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life

Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori

Condition

Condition

Subjects with gastric load of Helicobacter pylori

Participants

Participants

107 subjects (Age: 18-45 years)

Dose

Dose

150 mg/day before breakfast

Duration

Duration

60 days

Evaluation

Evaluation

On day 30 and day 60, using 13C-UBT and HpSA test

Outcome

Outcome

GutGard® showed 41% reduction in H. pylori load read more compared to the placebo. 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT.

Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.

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Research Image

GutGard® pre-clinical research

gutgard-research-objective

Objective

To determine the anti-ulcer and antioxidant potential of GutGard®

gutgard-research-dose

Dose

12.5, 25, and 50 mg per kg

gutgard-research-test

Test

The effect of GutGard® was studied on gastric read more ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.

gutgard-research-evaluation

Evaluation

Anti-ulcer activity was evaluated by measuring the ulcer read more index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.

gutgard-research-outcome

Outcome

GutGard® possessed anti-ulcerogenic properties read more that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.

gutgard-research-objective

Objective

To evaluate the gastroprokinetic effect of read more flavonoid-rich root extract of Glycyrrhiza glabra (GutGard®) and glabridin in albino Wistar rats using the phenol red meal model.

gutgard-research-test

Test

Gastroprokinetic effect using Phenol red meal model

gutgard-research-dose

Dose

Various dose levels of GutGard® (6.25, 12.5, and 25 mg per kg)

gutgard-research-evaluation

Evaluation

The gastroprokinetic effect of flavonoid-rich root read more extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.

gutgard-research-outcome

Outcome

Rats treated with GutGard® exhibited a read more statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard® and glabridin is comparable to domperidone, a potent prokinetic agent.

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GutGard®: Mechanisms of action

Various studies have shown that GutGard® supports digestive functioning
through several mechanisms of action:

  1. Possess antioxidant properties (Inhibits DPPH, ABTS) and possess good ORAC
  2. Works against H. pylori (in vitro inhibited H. pylori protein synthesis, DNA gyrase and dihydrofolate reductase)
  3. Acts as a prokinetic agent; modulates gut motility
  4. Reduces inflammatory mediators like PGE2, TXB2, LTB4 NO, IL-1beta and IL-6
  5. Acts as a gastroprotective
Gutgard BK
Gutgard Dosage Tablet

Dosage:

150 mg per day

Holixer Stands BK

GutGard®: Stands for things that matter to you

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Formulations possible with GutGard®

Formulations possible with AP-Bio
Capsule

Sachets

Capsule

Tablets

Capsule

Chews

Capsule

Beverages

Capsule

Shots

Capsule

Capsules

Capsule

Oral Strips

Applications of GutGard®

Probiotic count (cfu/ml)

GutGard Graph

Log Values

PB-Probiotic drink

GGPB-GutGard® + Probiotic drink

GutGard® works synergistically with Digestive Enzymes

GutGard® does not inhibit digestive enzymes, viz.Da-amylase, a-glucosidase, phytase, and xylanase

Enzymes

GutGard® was found to be safe when tested with these digestive enzymes

Acidophilus
  • GutGard® added to probiotic drink
  • Probiotic count remained at the acceptable level
  • Indicates GutGard® is compatible with tested probiotic drink
probiotic-bacteria

GutGard® tested against some common probiotic bacteria

safety-against

High MIC of GutGard® indicates the reasonable safety against these probiotic bacteria

water-activity

Water activity (aW) of GutGard® is less than 0.2

low-water-activity

Low water activity of GutGard® makes it suitable for probiotic powders

probiotic-drinks

Good compatibility with probiotic bacteria makes it suitable for probiotic drinks

gutgard video to learn more

Watch the GutGard® video to learn more.

GutGard® - Flavonoid-rich bioactive for daily digestive health

gutgard
Low dose allows forflexibility in formulations Works symbiotically with probiotics& digestiveenzymes Soft extraction process to retain and enrichthe goodnessof flavanoids Wide range of delivery applications like chews, gummies, beverages andpowders are possible. <0.5% glycyrrhizin ensures higher safety Clinically studied for relieving gastro-esophageal reflux related symptoms like heartburn & regurgitation Clinically studied tosupport management of Helicobacterpylori Clinically studied foralleviating symptoms of daily gut health issues High flavonoids(10% w/w) by HPLC and >50 different flavonoids identified by LC-MS Why choose ?

Why choose GutGard®?

beverages-powders

Wide range of delivery applications like chews, gummies, beverages and powders are possible.

helicobacter-pylori

Clinically studied to support management of Helicobacter pylori

higher-safety

<0.5% glycyrrhizin ensures higher safety

formulations

Low dose allows for flexibility in formulations

digestive-enzymes

Works symbiotically with probiotics and digestive enzymes

extraction-process

Soft extraction process to retain and enrich the goodness of flavanoids

clinically-studied

Clinically studied for alleviating symptoms of daily gut health issues

high-flavonoids

High flavonoids (10% w/w) by HPLC and >50 different flavonoids identified by LC-MS

Group-220617

Clinically studied for relieving gastro-esophageal reflux related symptoms like heartburn & regurgitation

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