Clinical Research
Mechanisms of Action
Health Claims
Dosage
Application of GutGard^®
Why Choose GutGard^®?

GutGard^® and it’s development gutgard and it’s development

GutGard^® and it’s development

Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. And, poor digestion leads to lack of energy, poor sleep, and overall malaise. Upper digestive ailments are also often caused by a bacterial infection, chiefly, Helicobacter pylori.

Over-the-counter remedies may work to reduce symptom severity, and prescriptions meant to take daily, regulate over-enthusiastic proton pumps in the stomach that eject the acid.

But natural remedies and dietary supplementation to support healthy digestion are an equal part of the equation, with the goal of lessening the need for rescue tools such as antacids.

Licorice, notably DGL (deglycyrrhized licorice) has been a fairly common botanical supplement used by consumers to aid digestion. Most of the licorice supplements on the market are DGL – this is because glycyrrhizin, a triterpene saponin found in licorice root, can induce adverse side effects such as reduced potassium and high blood pressure when ingested in high amounts.

GutGard^® goes beyond deglycyrrhization, as conventional DGL extracts lack bioactive flavonoids found in the root. GutGard^® is extracted using a unique extraction process that retrieves the bioactive flavonoid profile. It is standardized to contain 10% total flavonoids no more than 0.5% glycyrrhizin. And the key difference between GutGard^® and DGL extract is that DGL extracts typically contain negligible amounts of flavonoids – in fact, DGL is a product obtained following the removal of glycyrrhizin and is not standardized to any biologically active constituents. GutGard^® is closer to nature than DGL as acids are not used in its production process, whereas DGL production involves treatment with acids/alkali.

GutGard^® for daily digestive health gutgard and it’s development

GutGard^® for daily digestive health

GutGard^® is a clinically researched, flavonoid-rich, natural bioactive for daily digestive health derived from Glycyrrhiza glabra. GutGard^® is standardized to >3.5% glabridin and >10% total flavonoids with glycyrrhizin level to be made <0.5%

GutGard^® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard^® by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.

Traditional uses

Licorice has a long, rich use in cultures worldwide; it was even found in the tomb of King Tutankhamun. The dried root of licorice has been used by not only the Egyptians but throughout the populations and cultures of Asia and the Mediterranean regions. The Romans relied on it for numerous ailments. Licorice is recorded in the pharmacopoeias of nations throughout the world.

In the first century AD, the Greek physician Dioscorides used licorice to treat people with stomach and intestinal ulcers (it is known now that many ulcers are caused by Helicobacter pylori).

Licorice was revered by the ancient Egyptians who used it to make tonics that were placed in the canopic jars to accompany them into the afterlife. It is also said that legendary generals Julius Caesar, Alexander the Great, and Napoleon Bonaparte used licorice. In the Eurasian steppe, the Scythian tribes relied on licorice to survive when water was scarce.

GutGard^®: Backed by human clinical
studies for daily digestive health

Summary
Clinical Study 1
Clinical Study 2

Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori

Clinical study 1

GutGard^®significantly lowers the symptoms of daily digestive health problems (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)

GutGard^® improved quality of life

Clinical study 2

48% of the population in the GutGard^® group were relieved from H. pylori as assessed by 13C-UBT

Randomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.

Condition

Subjects with functional dyspepsia

Participants

50 subjects (Age: 18-65 years)

Dose

75 mg, two times a day after food

Duration

30 days

Evaluation

On day 15 and day 30

Outcome

GutGard^® effectively managed the symptoms read more of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard^® improved quality of life

Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012,Article ID 216970, 9 pages, 2012.

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Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori

Condition

Subjects with gastric load of Helicobacter pylori

Participants

107 subjects (Age: 18-45 years)

Dose

150 mg/day before breakfast

Duration

60 days

Evaluation

On day 30 and day 60, using 13C-UBT and HpSA test

Outcome

GutGard^® showed 41% reduction in H. pylori load read more compared to the placebo. 48% of the population in the GutGard^® group were relieved from H. pylori as assessed by 13C-UBT.

Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.

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GutGard^® pre-clinical research

Preclinical 1
Preclinical 2

Objective

To determine the anti-ulcer and antioxidant potential of GutGard^®

Dose

12.5, 25, and 50 mg per kg

Test

The effect of GutGard^® was studied on gastric read more ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.

Evaluation

Anti-ulcer activity was evaluated by measuring the ulcer read more index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard^® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.

Outcome

GutGard^® possessed anti-ulcerogenic properties read more that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.

Objective

To evaluate the gastroprokinetic effect of read more flavonoid-rich root extract of Glycyrrhiza glabra (GutGard^®) and glabridin in albino Wistar rats using the phenol red meal model.

Test

Gastroprokinetic effect using Phenol red meal model

Dose

Various dose levels of GutGard^® (6.25, 12.5, and 25 mg per kg)

Evaluation

The gastroprokinetic effect of flavonoid-rich root read more extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.

Outcome

Rats treated with GutGard^® exhibited a read more statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard^® and glabridin is comparable to domperidone, a potent prokinetic agent.