GutGard® and
it’s development
Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. And, poor digestion leads to lack of energy, poor sleep, and overall malaise. Upper digestive ailments are also often caused by a bacterial infection, chiefly, Helicobacter pylori.
GutGard® for daily digestive health
GutGard® is a clinically researched, flavonoid-rich, natural bioactive for daily digestive health derived from Glycyrrhiza glabra. GutGard®is standardized to >3.5% glabridin and >10% total flavonoids with glycyrrhizin level to be made <0.5%
GutGard® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard®by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.
Traditional uses 
Licorice has a long, rich use in cultures worldwide; it was even found in the tomb of King Tutankhamun. The dried root of licorice has been used by not only the Egyptians but throughout the populations and cultures of Asia and the Mediterranean regions. The Romans relied on it for numerous ailments. Licorice is recorded in the pharmacopoeias of nations throughout the world.
In the first century AD, the Greek physician Dioscorides used licorice to treat people with stomach and intestinal ulcers (it is known now that many ulcers are caused by Helicobacter pylori).
Licorice was revered by the ancient Egyptians who used it to make tonics that were placed in the canopic jars to accompany them into the afterlife. It is also said that legendary generals Julius Caesar, Alexander the Great, and Napoleon Bonaparte used licorice. In the Eurasian steppe, the Scythian tribes relied on licorice to survive when water was scarce.
GutGard®: Backed by human clinical studies for daily digestive health
Clinical study 1
- GutGard® significantly lowers the symptoms of daily digestive health problems (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)
- GutGard® improved quality of life
Clinical study 2
- 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT
Clinical Study 1
- GutGard® effectively managed the symptoms of Functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)
- GutGard® improved quality of life
Clinical Study 2
- GutGard® showed 41% reduction in H. pylori load compared to placebo
- 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT
Randomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.
Condition
Subjects with functional dyspepsia
Dose
75 mg, two times a day after food
Participants
50 subjects (Age: 18-65 years)
Duration
30 days
Evaluation
On day 15 and day 30
Outcome
GutGard® effectively managed the symptoms of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)
GutGard® improved quality of life
Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012,Article ID 216970, 9 pages, 2012.
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Effects of GutGard® on Functional Dyspepsia
Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori
Condition
Subjects with gastric load of Helicobacter pylori
Dose
150 mg/day before breakfast
Participants
107 subjects (Age: 18-45 years)
Duration
60 days
Evaluation
On day 30 and day 60, using 13C-UBT and HpSA test
Outcome
GutGard® showed 41% reduction in H. pylori load compared to the placebo. 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT.
Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.
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Effects of GutGard® on H. pylori
GutGard® pre-clinical research
Objective
To determine the anti-ulcer and antioxidant potential of GutGard®
Evaluation
Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.
Test
The effect of GutGard® was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.
Outcome
GutGard® possessed anti-ulcerogenic properties that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
Dosage
12.5, 25, and 50 mg per kg
Objective
To evaluate the gastroprokinetic effect of flavonoid-rich root extract of Glycyrrhiza glabra (GutGard®) and glabridin in albino Wistar rats using the phenol red meal model.
Test
Gastroprokinetic effect using Phenol red meal model
Evaluation
The gastroprokinetic effect of flavonoid-rich root extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.
Dosage
Various dose levels of GutGard® (6.25, 12.5, and 25 mg per kg)
Outcome
Rats treated with GutGard® exhibited a statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard® and glabridin is comparable to domperidone, a potent prokinetic agent.
GutGard®: Mechanism of action
Works against H. pylori (in vitro inhibited H. pylori protein synthesis, DNA gyrase and dihydrofolate reductase)
Health benefits
150mg per day
Helps manage daily gut health issues - upper abdominal fullness, upper abdominal pain, nausea, bloating, belching & regulations*
Promotes daily gut health*
Relief from meal triggered indigestion*
Support management of H. pylori*
Dosage*
150 mg per day
Applications of GutGard®
Probiotic count (cfu/ml)
- GutGard® added to probiotic drink (Lactobacillus acidophilus)
- This indicates GutGard® is compatible with tested probiotic drink
- Probiotic count remained at the acceptable level
GutGard® can be combined with the Digestive Enzymes
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