Flavonoid-rich bioactive
for daily digestive health
- Clinical Research
- Mechanisms of Action
- Health Claims
- Dosage
- Application of GutGard®
- Why Choose GutGard®?
GutGard® and it’s development
Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. And, poor digestion leads to lack of energy, poor sleep, and overall malaise. Upper digestive ailments are also often caused by a bacterial infection, chiefly, Helicobacter pylori.
Read MoreOver-the-counter remedies may work to reduce symptom severity, and prescriptions meant to take daily, regulate over-enthusiastic proton pumps in the stomach that eject the acid.
But natural remedies and dietary supplementation to support healthy digestion are an equal part of the equation, with the goal of lessening the need for rescue tools such as antacids.
Licorice, notably DGL (deglycyrrhized licorice) has been a fairly common botanical supplement used by consumers to aid digestion. Most of the licorice supplements on the market are DGL – this is because glycyrrhizin, a triterpene saponin found in licorice root, can induce adverse side effects such as reduced potassium and high blood pressure when ingested in high amounts.
GutGard® goes beyond deglycyrrhization, as conventional DGL extracts lack bioactive flavonoids found in the root. GutGard® is extracted using a unique extraction process that retrieves the bioactive flavonoid profile. It is standardized to contain 10% total flavonoids no more than 0l.% glycyrrhizin. And the key difference between GutGard® and DGL extract is that DGL extracts typically contain negligible amounts of flavonoids – in fact, DGL is a product obtained following the removal of glycyrrhizin and is not standardized to any biologically active constituents. GutGard® is closer to nature than DGL as acids are not used in its production process, whereas DGL production involves treatment with acids/alkali.
GutGard® for daily digestive health
GutGard® is a clinically researched, flavonoid-rich, natural bioactive for daily digestive health derived from Glycyrrhiza glabra. GutGard® is standardized to >3.5% glabridin and >10% total flavonoids with glycyrrhizin level to be made <0.5%
Read MoreGutGard® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard® by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.
Traditional uses
Licorice has a long, rich use in cultures worldwide; it was even found in the tomb of King Tutankhamun. The dried root of licorice has been used by not only the Egyptians but throughout the populations and cultures of Asia and the Mediterranean regions. The Romans relied on it for numerous ailments. Licorice is recorded in the pharmacopoeias of nations throughout the world.
Read MoreIn the first century AD, the Greek physician Dioscorides used licorice to treat people with stomach and intestinal ulcers (it is known now that many ulcers are caused by Helicobacter pylori).
Licorice was revered by the ancient Egyptians who used it to make tonics that were placed in the canopic jars to accompany them into the afterlife. It is also said that legendary generals Julius Caesar, Alexander the Great, and Napoleon Bonaparte used licorice. In the Eurasian steppe, the Scythian tribes relied on licorice to survive when water was scarce.
GutGard®: Backed by human clinical
studies for daily digestive health
- Summary
- Clinical Study 1
- Clinical Study 2
Clinical study 1
GutGard® significantly lowers the symptoms of daily digestive health problems (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life
Clinical study 2
48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT
Randomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.
Condition
Subjects with functional dyspepsia
Participants
50 subjects (Age: 18-65 years)
Evaluation
On day 15 and day 30
Dose
75 mg, two times a day after food
Duration
30 days
Outcome
GutGard® effectively managed the symptoms read more of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life
Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012,Article ID 216970, 9 pages, 2012.
Know MoreRandomized double-blind, placebo-controlled clinical study in subjects with H. pylori
Condition
Subjects with gastric load of Helicobacter pylori
Participants
107 subjects (Age: 18-45 years)
Evaluation
On day 30 and day 60, using 13C-UBT and HpSA test
Dose
150 mg/day before breakfast
Duration
60 days
Outcome
GutGard® showed 41% reduction in H. pylori load read more compared to the placebo. 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT.
Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.
Know More
GutGard® pre-clinical research
- Preclinical 1
- Preclinical 2
Objective
To determine the anti-ulcer and antioxidant potential of GutGard®
Dose
12.5, 25, and 50 mg per kg
Test
The effect of GutGard® was studied on gastric read more ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.
Evaluation
Anti-ulcer activity was evaluated by measuring the ulcer read more index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.
Outcome
GutGard® possessed anti-ulcerogenic properties read more that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
Objective
To evaluate the gastroprokinetic effect of read more flavonoid-rich root extract of Glycyrrhiza glabra (GutGard®) and glabridin in albino Wistar rats using the phenol red meal model.
Test
Gastroprokinetic effect using Phenol red meal model
Dose
Various dose levels of GutGard® (6.25, 12.5, and 25 mg per kg)
Evaluation
The gastroprokinetic effect of flavonoid-rich root read more extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.
Outcome
Rats treated with GutGard® exhibited a read more statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard® and glabridin is comparable to domperidone, a potent prokinetic agent.
GutGard®: Mechanisms of action
Various studies have shown that GutGard® supports digestive functioning
through several mechanisms of action:
- Possess antioxidant properties (Inhibits DPPH, ABTS) and possess good ORAC
- Works against H. pylori (in vitro inhibited H. pylori protein synthesis, DNA gyrase and dihydrofolate reductase)
- Acts as a prokinetic agent; modulates gut motility
- Reduces inflammatory mediators like PGE2, TXB2, LTB4 NO, IL-1beta and IL-6
- Acts as a gastroprotective
Health Claims*
The human clinical study on GutGard® allows for the following health claims:
- USA
- Korea
- ROW
Helps to manage occasional indigestion including fullness and gas
Helps to manage occasional heartburn
Helps to maintain healthy stomach
Supports gut immunity
Can help stomach health by inhibiting the proliferation of Helicobacter pylori in stomach mucosal layer and by protecting stomach mucosal layer
Helps to manage occasional indigestion including fullness and gas
Helps to manage occasional heartburn
Supports management of H. pylori
Helps to maintain healthy stomach
Can help stomach health by inhibiting the proliferation of Helicobacter pylori in stomach mucosal layer and by protecting stomach mucosal layer
Supports gut immunity
Dosage:
150 mg per day
Applications of GutGard®
- Probiotic Combination With Gutgard®
- Gutgard® Can Be Combined With Digestive Enzymes
Probiotic count (cfu/ml)
Log Values
PB-Probiotic drink
GGPB-GutGard® + Probiotic drink
Gutgard® Can Be Combined With Digestive Enzymes
GutGard® does not inhibit digestive enzymes, viz.Da-amylase, a-glucosidase, phytase, and xylanase
GutGard® was found to be safe when tested with these digestive enzymes
- GutGard® added to probiotic drink (Lactobacillus acidophilus)
- This indicates GutGard® is compatible with tested probiotic drink
- Probiotic count remained at the acceptable level
| Probiotic bacteria |
|---|
| Lactobacillus casei |
| Lactobacillus fermentum |
| Lactobacillus fermentum |
| Streptococcus thermophilus |
| MIC (µg/ml) of GutGard® |
|---|
| 7,500 |
| 7,500 |
| 7,500 |
| >10,000 |
GutGard® tested against some common probiotic bacteria
High MIC of GutGard® indicates the reasonable safety against these probiotic bacteria
Water activity (aW) of GutGard® is less than 0.2
Low water activity of GutGard® makes it suitable for probiotic powders
Good compatibility with probiotic bacteria makes it suitable for probiotic drinks
Watch the GutGard® video to learn more.
GutGard® - Flavonoid-rich bioactive for daily digestive health
Why choose GutGard®?
Wide range of delivery applications like chews, gummies, beverages and powders are possible.
Clinically studied to support management of Helicobacter pylori
<0.5% glycyrrhizin ensures higher safety
Low dose allows for flexibility in formulations
Works symbiotically with probiotics and digestive enzymes
Soft extraction process to retain and enrich the goodness of flavanoids
Clinically studied for alleviating symptoms of daily gut health issues
High flavonoids (10% w/w) by HPLC and >50 different flavonoids identified by LC-MS
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