Holixer - Herbal Stress Supplement

  • Innovation
  • Clinical Research
  • Mechanisms of Action
  • Health Claims
  • Dosage
  • Formulations
  • Why choose Holixer?
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Holixer and it’s development holixer and it’s development

Holixer and it’s development

People all over the world have two health concerns in common: high, chronic stress and its impact on healthy sleep. These issues are rising, unfortunately.

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A longstanding Ayurvedic herb, Tulsi (also known as Holy Basil, Ocimum tenuiflorum) is commonly used as an adaptogen, which helps the body to physiologically attain healthful balance. When in the state of healthful balance, the body can more easily adapt to stressors, and this can set the stage for sleep improvement.

Holixer is a unique Tulsi extract supported by human clinical research demonstrating value for stress management and reduction, improved sleep and higher quality of life. Beyond ashwagandha, tulsi is gaining tremendous interest from consumers dealing with hypersomnia, parasomnia, insomnia and various types of anxiety, such as social anxiety, and test/performance anxiety.

Tulsi extract is on par with ashwagandha for the management of stress, sleep quality, calm, good mood and overall quality of mental-emotional life.

Through innovative technology (patent-pending), Holixer features the Holy Basil X factor. It is a low-dose solution for stress and sleep quality.

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Traditional uses holixer Traditional uses

Traditional uses

Traditional Use of Tulsi/Holy Basil Tulsi has powerful significance in Ayurveda, where it is revered as “Mother Medicine of Nature” and “The Queen of Herbs,” as well as being referred to as “an elixir of life.” Throughout India, tulsi is used in lifestyle practices and spiritual rituals.

Ayurvedic physicians use tulsi for their patients to normalize kapha and vata - this supports its use in modern herbal supplementation as an adaptogen. The healing properties of tulsi have been researched in hundreds of in vitro, animal and human studies, all showing a range of benefits including adaptogenic and anti-stress capabilities. To date, there are 1,014 published research articles on tulsi.

Innovation BK

Innovation

Natural Remedies’ research and development team worked diligently for five years to create Bioactive Optimization Technology (B.O.T), a systematic technique that preserves the multiple bioactive compounds in Holy Basil and optimizes their innate capabilities.

This bioactives-enhancement technology results in Ocimum-Bioactive Complex (OBC), providing our brand partners and their consumers with a measurable, distinctive Holy Basil herbal extract that is incomparable to all others.

Innovation Point
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Human Clinical Evidence of Holixer

Everyday Stress

Everyday Stress

Everyday Stress (Chronic Stress)

  • Perceived Stress Scale (PSS)
  • Hair Cortisol
Acute Stress

Acute Stress

Acute Stress

  • MAST (Maastricht Acute Stress Test)
Sleep

Sleep

Athens Insomnia Scale (AIS)

  • Sleep Quality

Fitbit®: Worn every night to bed

  • Sleep Efficiency
Quality of life (QoL)

Quality of life (QoL)

Promis

  • Physical Function, Anxiety, Depression, Fatigue, Sleep disturbance & Social
Condition

Condition

Healthy participants with stress and sleep problems

Participants

Participants

100 volunteers (n=50 in each group)

Dose

Dose

250 mg/day

Duration

Duration

8 weeks

Evaluation - Stress:

Evaluation - Stress:

Subjective: Perceived stress scale (PSS), Visual analogue scale (VAS) read more | Objective: Hair cortisol, Salivary cortisol, Salivary alpha amylase (sAA), Blood Pressure

Evaluation Sleep:

Evaluation Sleep:

Subjective: Athens Insomnia Scale (AIS) Objective: Fitbit®

Evaluation QOL:

Evaluation QOL:

Subjective: PROMIS 29

Outcome

Outcome

Holixer demonstrated significantly greater improvements in stress and read more sleep scores compared to the placebo

Lopresti et al. (2022) Front. Nutr . 9:965130. doi:10.3389/fnut.2022.96513

Everyday stress: Perceived Stress Scale (PSS) - Subjectivee

Effect of Holixer & Placebo on change in the Perceived stress scale (PSS)

Holixer Graph Holixer PSS Graph

Placebo

Holixer

2W

Holixer start showing effect within two weeks

2X

Holixer reduced the stress scores two times compared to placebo

Holixer showed significant reduction in Perceived Stress Score with 38% VS placebo.

*Statistically-significant between-group difference in change in PSS scores over time (P = .009).

Everyday stress: Hair cortisol Objective

Effect of Holixer & Placebo on change in Hair cortisol concentration

Holixer Everyday Stress Graph

Holixer showed statistically significant lower hair cortisol concentration compared to placebo.

! Statistically significant lower concentration in hair cortisol (p=0.03). After 8 weeks of intake !

Acute stress: Salivary cortisol- Objective

Effect of Holixer & Placebo on Salivary cortisol

Holixer Acute Stress Cortisol Graph

Placebo

Holixer

Benefits in acute stress was strongly correlated WIth reduction in salivary cortisol within 10 minutes (Holixer 113% Vs Placebo 163%).

Acute stress: Salivary alpha amylase (sAA) -Objective

Effect of Holixer & Placebo on Salivary alpha amylase (sAA)

Holixer Amylase Graph

Placebo

Holixer

Benefits in acute stress was strongly correlated with reduction in salivary alpha amylase within 10 minutes.

Sleep: Athens Insomnia Scale (AIS) - Subjective

Effect of Holixer & Placebo on sleep

Holixer Insomnia Graph

Placebo

Holixer

Holixer showed 50% improvement in sleep as compared to placebo.

*Statistically-significant (p<.025)

Sleep: Wearable Sleep tracker (Fitbit®) - Objective

Effect of Holixer & Placebo on sleep

Holixer Sleep Tracker Graph

Placebo

Holixer

Holixer Fitbit Graph

Holixer showed significant improvement in sleep efficiency from the baseline.

* Statistically significant from baseline

QoL-PROMIS 29 Scale- Subjective

Holixer Quality Life Graph

Marked improvement in Fatigue, Anxiety & Sleep distrubance

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Holixer Mechanisms of Action

Holixer Mechanism of Action
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Health Claims*

The human clinical study on Holixer allows for the following health claims:

Everyday Stress

Helps maintain healthy cortisol levels during everyday stress

Everyday Stress

Regular intake helps the body quickly respond when facing acute stress

Everyday Stress

Helps you work relaxed during everyday stress

Everyday Stress

For resolving the irritability that ruins the day

Everyday Stress

Helps in physical and mental well-being during everyday stress

Everyday Stress

Day and night-time aid for everyday stress and occasional sleeplessness

Everyday Stress

Helps to be calm during everyday stress

Everyday Stress

Support resilience to combat everyday stressors

Everyday Stress

Helps improve sleep efficiency during occasional sleeplessness

Everyday Stress

Non-drowsy calm aid

Everyday Stress

Stay asleep longer during occasional sleeplessness naturally

Everyday Stress

Helps to maintain vitality*

Everyday Stress

Helps to maintain resistance to stress*

Everyday Stress

Helps maintain healthy cortisol levels during everyday stress

Everyday Stress

Regular intake helps the body quickly respond when facing acute stress

Everyday Stress

Helps you work relaxed during everyday stress

Everyday Stress

For resolving the irritability that ruins the day

Everyday Stress

Helps in physical and mental well-being during everyday stress

Everyday Stress

Day and night-time aid for everyday stress and occasional sleeplessness

Everyday Stress

Helps to be calm during everyday stress

Everyday Stress

Support resilience to combat everyday stressors

Everyday Stress

Helps improve sleep efficiency during occasional sleeplessness

Everyday Stress

Non-drowsy calm aid

Everyday Stress

Stay asleep longer during occasional sleeplessness naturally

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Holixer dosage BK Holixer dosage BG
Holixer Dosage Tablet

Dosage:

Low dose 250 mg/day
(in single or two divided doses)

Holixer Stands BK

Holixer: Stands for the things that matter to you

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Formulations possible with Holixer

Formulations possible with Holixer
Holixer Capsule

Capsule

Holixer Sachets

Sachets

Holixer Gummies

Gummies

Holixer Tablet

Tablet

Holixer Shots

Shots

Holixer Effervescent powders

Effervescent powders

Holixer: Sustainably making a difference at everystep

Holixer has an attractive sustainability story that will meet consumers’ high standards. The raw material Holy Basil plants are grown and cultivated in accordance with Good Agricultural Practices, with natural nutrient-rich fertilizers and without the use of pesticides. The entire process allows for Natural Remedies to have end-to-end control over biomass.

Holixer: Sustainably making a difference at everystep

Holixer-Sustainably making a difference at everystep
Watch the Holixer video to learn more.

Watch the Holixer video to learn more.

Holixer – Low Dose Solution for Stress & Sleep Quality.

Backed by clinical study done on Australiansubjects TM - Superscript Unique Ocimum-bioactivecomplex chemistry Stress evaluated using unique objectivee paraments like MAST & Hair cortisol Organic gradesavailable Pioneers in Ocimum(Holy Basil) brands Relevant & scientifically validatedclaims on stress & sleep Low dose250 mg/day WhychooseHolixerTM ?

Why Choose Holixer?

Low dose 250 mg/day

Low dose 250 mg/day

Unique Ocimum-bioactive complex chemistry

Unique Ocimum-bioactive complex chemistry

Pioneers in Ocimum (Holy Basil) brands

Pioneers in Ocimum (Holy Basil) brands

TM - Superscript

TM - Superscript

Backed by clinical study done on Australian subjects

Backed by clinical study done on Australian subjects

Organic grades available

Organic grades available

Stress evaluated using unique objective paraments like MAST & Hair cortisol

Stress evaluated using unique objective paraments like MAST & Hair cortisol

Relevant & scientifically validated claims on stress & sleep

Relevant & scientifically validated claims on stress & sleep

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