- Innovation
- Clinical Research
- Mechanisms of Action
- Health Claims
- Dosage
- Formulations
- Why choose Holixer™?
Holixer™ and it’s development
People all over the world have two health concerns in common: high, chronic stress and its impact on healthy sleep. These issues are rising, unfortunately.
Read MoreA longstanding Ayurvedic herb, Tulsi (also known as Holy Basil, Ocimum tenuiflorum) is commonly used as an adaptogen, which helps the body to physiologically attain healthful balance. When in the state of healthful balance, the body can more easily adapt to stressors, and this can set the stage for sleep improvement.
Holixer™ is a unique Tulsi extract supported by human clinical research demonstrating value for stress management and reduction, improved sleep and higher quality of life. Beyond ashwagandha, tulsi is gaining tremendous interest from consumers dealing with hypersomnia, parasomnia, insomnia and various types of anxiety, such as social anxiety, and test/performance anxiety.
Tulsi extract is on par with ashwagandha for the management of stress, sleep quality, calm, good mood and overall quality of mental-emotional life.
Through innovative technology (patent-pending), Holixer™ features the Holy Basil X factor. It is a low-dose solution for stress and sleep quality.
Traditional uses
Traditional Use of Tulsi/Holy Basil Tulsi has powerful significance in Ayurveda, where it is revered as “Mother Medicine of Nature” and “The Queen of Herbs,” as well as being referred to as “an elixir of life.” Throughout India, tulsi is used in lifestyle practices and spiritual rituals.
Ayurvedic physicians use tulsi for their patients to normalize kapha and vata - this supports its use in modern herbal supplementation as an adaptogen. The healing properties of tulsi have been researched in hundreds of in vitro, animal and human studies, all showing a range of benefits including adaptogenic and anti-stress capabilities. To date, there are 1,014 published research articles on tulsi.
Innovation
Natural Remedies’ research and development team worked diligently for five years to create Bioactive Optimization Technology (B.O.T™), a systematic technique that preserves the multiple bioactive compounds in Holy Basil and optimizes their innate capabilities.
This bioactives-enhancement technology results in Ocimum-Bioactive Complex (OBC), providing our brand partners and their consumers with a measurable, distinctive Holy Basil herbal extract that is incomparable to all others.
Human Clinical Evidence of Holixer™
- Summary
- Overview
- Everyday Stress (Chronic Stress)
- Acute Stress
- Sleep
- Quality Of Life (QoL)
Everyday Stress
Everyday Stress (Chronic Stress)
- Perceived Stress Scale (PSS)
- Hair Cortisol
Acute Stress
Acute Stress
- MAST (Maastricht Acute Stress Test)
Sleep
Athens Insomnia Scale (AIS)
- Sleep Quality
Fitbit®: Worn every night to bed
- Sleep Efficiency
Quality of life (QoL)
Promis
- Physical Function, Anxiety, Depression, Fatigue, Sleep disturbance & Social
Condition
Healthy participants with stress and sleep problems
Participants
100 volunteers (n=50 in each group)
Dose
250 mg/day
Duration
8 weeks
Evaluation - Stress:
Subjective: Perceived stress scale (PSS), Visual analogue scale (VAS) read more | Objective: Hair cortisol, Salivary cortisol, Salivary alpha amylase (sAA), Blood Pressure
Evaluation Sleep:
Subjective: Athens Insomnia Scale (AIS) Objective: Fitbit®
Evaluation QOL:
Subjective: PROMIS 29
Outcome
Holixer™ demonstrated significantly greater improvements in stress and read more sleep scores compared to the placebo
Lopresti et al. (2022) Front. Nutr . 9:965130. doi:10.3389/fnut.2022.96513
Everyday stress: Perceived Stress Scale (PSS) - Subjectivee
Effect of Holixer™ & Placebo on change in the Perceived stress scale (PSS)
Placebo
Holixer™
2W
Holixer™ start showing effect within two weeks
2X
Holixer™ reduced the stress scores two times compared to placebo
Holixer™ showed significant reduction in Perceived Stress Score with 38% VS placebo.
*Statistically-significant between-group difference in change in PSS scores over time (P = .009).
Everyday stress: Hair cortisol Objective
Effect of Holixer™ & Placebo on change in Hair cortisol concentration
Holixer™ showed statistically significant lower hair cortisol concentration compared to placebo.
! Statistically significant lower concentration in hair cortisol (p=0.03). After 8 weeks of intake !
Acute stress: Salivary cortisol- Objective
Effect of Holixer™ & Placebo on Salivary cortisol
Placebo
Holixer™
Benefits in acute stress was strongly correlated WIth reduction in salivary cortisol within 10 minutes (Holixer 113% Vs Placebo 163%).
Acute stress: Salivary alpha amylase (sAA) -Objective
Effect of Holixer™ & Placebo on Salivary alpha amylase (sAA)
Placebo
Holixer™
Benefits in acute stress was strongly correlated
with reduction in salivary alpha amylase
within 10 minutes.
Sleep: Athens Insomnia Scale (AIS) - Subjective
Effect of Holixer™ & Placebo on sleep
Placebo
Holixer™
Holixer™ showed 50% improvement in sleep as compared to placebo.
*Statistically-significant (p<.025)
Sleep: Wearable Sleep tracker (Fitbit®) - Objective
Effect of Holixer™ & Placebo on sleep
Placebo
Holixer™
Holixer™ showed significant improvement in sleep efficiency from the baseline.
* Statistically significant from baseline
QoL-PROMIS 29 Scale- Subjective
Marked improvement in Fatigue, Anxiety & Sleep distrubance
Holixer™ Mechanisms of Action
Health Claims*
The human clinical study on Holixer™ allows for the following health claims:
- USA
- Europe
- ROW
Helps maintain healthy cortisol levels during everyday stress
Regular intake helps the body quickly respond when facing acute stress
Helps you work relaxed during everyday stress
For resolving the irritability that ruins the day
Helps in physical and mental well-being during everyday stress
Day and night-time aid for everyday stress and occasional sleeplessness
Helps to be calm during everyday stress
Support resilience to combat everyday stressors
Helps improve sleep efficiency during occasional sleeplessness
Non-drowsy calm aid
Stay asleep longer during occasional sleeplessness naturally
Helps to maintain vitality*
Helps to maintain resistance to stress*
Helps maintain healthy cortisol levels during everyday stress
Regular intake helps the body quickly respond when facing acute stress
Helps you work relaxed during everyday stress
For resolving the irritability that ruins the day
Helps in physical and mental well-being during everyday stress
Day and night-time aid for everyday stress and occasional sleeplessness
Helps to be calm during everyday stress
Support resilience to combat everyday stressors
Helps improve sleep efficiency during occasional sleeplessness
Non-drowsy calm aid
Stay asleep longer during occasional sleeplessness naturally
Dosage:
Low dose 250 mg/day
(in single or two divided doses)
Holixer™: Stands for the things that matter to you
Formulations possible with Holixer™
Capsule
Sachets
Gummies
Tablet
Shots
Effervescent powders
Holixer™: Sustainably making a difference at everystep
Holixer™ has an attractive sustainability story that will meet consumers’ high standards. The raw material Holy Basil plants are grown and cultivated in accordance with Good Agricultural Practices, with natural nutrient-rich fertilizers and without the use of pesticides. The entire process allows for Natural Remedies to have end-to-end control over biomass.
Holixer™: Sustainably making a difference at everystep
Watch the Holixer™ video to learn more.
Holixer™ – Low Dose Solution for Stress & Sleep Quality.
Why Choose Holixer™?
Low dose 250 mg/day
Unique Ocimum-bioactive complex chemistry
Pioneers in Ocimum (Holy Basil) brands
TM - Superscript
Backed by clinical study done on Australian subjects
Organic grades available
Stress evaluated using unique objective paraments like MAST & Hair cortisol
Relevant & scientifically validated claims on stress & sleep