Holixer & Its development
Holixer & Its development

People all over the world have two health concerns in common: high, chronic stress and its impact on healthy sleep. These issues are rising, unfortunately.

A longstanding Ayurvedic herb, Tulsi (also known as Holy Basil, Ocimum tenuiflorum) is commonly used as an adaptogen, which helps the body to physiologically attain healthful balance. When in the state of healthful balance, the body can more easily adapt to stressors, and this can set the stage for sleep improvement.

HolixerTM is a unique Tulsi extract supported by human clinical research demonstrating value for stress management and reduction, improved sleep and higher quality of life. Beyond ashwagandha, tulsi is gaining tremendous interest from consumers dealing with hypersomnia, parasomnia, insomnia and various types of anxiety, such as social anxiety, and test/performance anxiety.

Tulsi extract is on par with ashwagandha for the management of stress, sleep quality, calm, good mood and overall quality of mental-emotional life.

Through innovative technology (patent-pending), HolixerTM features the Holy Basil X factor. It is a low-dose solution for stress and sleep quality.

Traditional Uses downlod arrow

Traditional Use of Tulsi/Holy Basil Tulsi has powerful significance in Ayurveda, where it is revered as “Mother Medicine of Nature” and “The Queen of Herbs,” as well as being referred to as “an elixir of life.” Throughout India, tulsi is used in lifestyle practices and spiritual rituals.

Ayurvedic physicians use tulsi for their patients to normalize kapha and vata - this supports its use in modern herbal supplementation as an adaptogen. The healing properties of tulsi have been researched in hundreds of in vitro, animal and human studies, all showing a range of benefits including adaptogenic and anti-stress capabilities. To date, there are 1,014 published research articles on tulsi.

Innovation

Innovation
Innovation

Natural Remedies’ research and development team worked diligently for five years to create Bioactive Optimization Technology (BOTTM), a systematic technique that preserves the multiple bioactive compounds in Holy Basil and optimizes their innate capabilities.

This bioactives-enhancement technology results in Ocimum-Bioactive Complex (OBC), providing our brand partners and their consumers with a measurable, distinctive Holy Basil herbal extract that is incomparable to all others.

every day stress

Everyday Stress (Chronic Stress)

  • Perceived Stress Scale (PSS)
  • Hair Cortisol
acute stress

Acute Stress

  • MAST (Maastricht Acute Stress Test)
sleep

Athens Insomnia Scale (AIS)

  • Sleep Quality

Fitbit®: Worn every night to bed

  • Sleep Efficiency
quality of life

PROMIS

Physical Function, Anxiety, Depression, Fatigue, Sleep disturbance & Social

Condition

Condition

Healthy participants with stress and sleep problems

dosage

Dose

250 mg/day

Participants

Participants

100 volunteers (n=50 in each group)

Duration

Duration

8 weeks

Evaluation - Stress

Evaluation - Stress:

Subjective: Perceived stress scale (PSS), Visual analogue scale (VAS)

Objective: Hair cortisol, Salivary cortisol, Salivary alpha amylase (sAA), Blood Pressure

Evaluation Sleep

Evaluation Sleep:

Subjective: Athens Insomnia Scale (AIS)

Objective: Fitbit®

Evaluation QOL

Evaluation QOL:

Subjective: PROMIS 29

outcome

Outcome

HolixerTM demonstrated significantly greater improvements in stress and sleep scores compared to the placebo

Everyday stress: Perceived Stress Scale (PSS) - Subjective
Everyday stress:Hair cortisol - Objective
Acute stress: Salivary  cortisol - Objective
Acute stress: Salivary alpha  amylase (sAA) - Objective
sleep: Athens insomnia scale-subjective
sleep:Wearable sleep tracker-objective

QoL-PROMIS 29 Scale- Subjective

Quality Of Life (Qol)

Marked improvement in Fatigue, Anxiety & Sleep distrubance

Holixer’sTM Human Clinical Evidence

Summary
every day stress

Everyday Stress (Chronic Stress)

  • Perceived Stress Scale (PSS)
  • Hair Cortisol
acute stress

Acute Stress

  • MAST (Maastricht Acute Stress Test)
sleep

Athens Insomnia Scale (AIS)

  • Sleep Quality

Fitbit®: Worn every night to bed

  • Sleep Efficiency
quality of life

PROMIS

Physical Function, Anxiety, Depression, Fatigue, Sleep disturbance & Social

Overview
  • Condition

    Condition

    Healthy participants with stress and sleep problems

  • dosage

    Dose

    250 mg/day

  • Participants

    Participants

    100 volunteers (n=50 in each group)

  • Duration

    Duration

    8 weeks

  • Evaluation stress

    Evaluation - Stress:

    Subjective: Perceived stress scale (PSS), Visual analogue scale (VAS).

    Objective: Hair cortisol, Salivary cortisol, Salivary alpha amylase (sAA), Blood Pressure.

  • Evaluation sleep

    Evaluation - sleep:

    Subjective: Athens Insomnia Scale (AIS).

    Objective: Fitbit®

  • Evaluation QOL

    Evaluation-QOL:

    Subjective: PROMIS 29

  • outcome

    Outcome:

    HolixerTM demonstrated significantly greater improvements in stress and sleep scores compared to the placebo

Everyday Stress(Chronic Stress)
Everyday stress: Perceived Stress Scale (PSS) - Subjective
Everyday stress:Hair cortisol - Objective
Acute Stress
Acute stress: Salivary  cortisol - Objective
Acute stress: Salivary alpha  amylase (sAA) - Objective
Sleep
sleep: Athens insomnia scale-subjective
sleep:Wearable sleep tracker-objective
Quality Of Life (QoL)

QoL-PROMIS 29 Scale- Subjective

Quality Of Life (Qol)

Marked improvement in Fatigue, Anxiety & Sleep distrubance

HolixerTM Mechanism of Action

HolixerTM Mechanism of Action
HolixerTM Mechanism of Action

Health Claims*

The human clinical study on HolixerTM allows for the following health claims:

  • Helps maintain healthy cortisol levels during everyday stress.
  • Helps the body to quickly respond when facing acute stress.
  • Helps support relaxation during everyday stress.
  • Helps resolve/reduce irritability, tension, and edginess.
  • Helps promote physical and mental well-being during everyday stress.
  • Supports resilience to combat everyday stressors.
  • Helps improve sleep efficiency during occasional sleeplessness and restlessness.
  • Helps the body to achieve longer duration of sleep.
  • Acts to induce non-drowsy calmness.

Dosage:

Low dose 250 mg/day (in single or two divided doses)

HolixerTM: Stands for the things that matter to you

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Formulations possible with HolixerTM

Formulations possible with Holixer
Formulations possible with Holixer
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farming
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HolixerTM: Sustainably making a difference at every step

HolixerTM has an attractive sustainability story that will meet consumers’ high standards. The raw material Holy Basil plants are grown and cultivated in accordance with Good Agricultural Practices, with natural nutrient-rich fertilizers and without the use of pesticides. The entire process allows for Natural Remedies to have end-to-end control over biomass.

Watch the video to learn more.

Why Choose HolixerTM?

Why choose Holixer
Why choose Holixer Why choose Holixer

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*Disclaimer: This website may contain statements and classification about product(s), which may not be in line with the regulations of your country. The statement or claims made are in reference to the ingredient only and therefore do not refer to any finished product directly or indirectly. The claims on the finished product containing our ingredient are the sole responsibility of manufacturer or the marketer. We urge manufacturer and marketer to ensure that the claims made on the finished product comply with the law and regulation of the country in which the product is to be sold. Statements used in this website have not been evaluated by FDA. The ingredient mentioned here is not intended to diagnose, treat, cure or prevent any disease.