Turmacin® and it’s development
Along with its rich history of use, turmeric’s scientific portfolio is also rich in evidence in its use particularly for managing inflammation and supporting joint health. Joint health is one of the top concerns among adults globally, as the fear of losing mobility to aggressively worsening osteoarthritis is common.
Turmacin® is an innovative clinically researched ingredient that brings the joint and cartilage health benefits of turmeric to dietary supplements. Featuring water-soluble TurmerosaccharidesTM, our patented, bioactive polysaccharide, Turmacin® is the clean label, natural way to add joint and cartilage support functionality to your formulation.
As there is a bevy of turmeric extracts that focus on the content of standardized curcuminoids, the opportunity to develop an effective and safe extract that focuses on the power of its unique polysaccharides has proven worthy.
Traditional uses 
Turmeric has a very long history of culinary, cosmetic, and medicinal use. Throughout Asia and India, there is substantial use of turmeric in traditional medical modalities to fight inflammation and pain.
In Ayurveda practices, turmeric is well-documented to have several useful actions for the treatment of rheumatism, sprains/swelling, and other conditions characterized by inflammation. Ayurvedic texts include dosage forms such as svarasa (juice), kalka (bolus/paste), kvatha (decoction), hima (cold infusion), phaṇṭa (hot infusion), and curna (powder).
In Indian culture, turmeric is held in high esteem beyond just for healing purposes. Hindus hold the herb sacred and it is part of a wedding tradition where the groom ties mangala sutra, a string dyed yellow from turmeric around the bride’s neck in a loving, symbolic gesture. And in South India, men and women who want to protect themselves from evil spirits will wear a turmeric rhizome piece as an amulet.
Water-soluble and oil-soluble
components of turmeric
The vast majority of research on turmeric-based products has been conducted on:
- Whole turmeric powder
- Volatile oil portions of turmeric
- Isolated curcuminoid extracts (especially curcumin)
Meanwhile, over 90% of the remaining water-soluble constituents of turmeric have been neglected and rarely investigated for their own health benefits. That begs the question: what have we been throwing away?
At Natural Remedies, we were on a quest to discover these unexplored components of turmeric. After years and years of research by our team of herbalists and scientists, we discovered that turmeric also contains a special class of water-soluble polysaccharides that are potent, promising, and bioactive. We named them Turmerosaccharides™.
Turmacin® is backed by 5 clinical studies:
Clinical Study 1
Turmacin® effectively managed the symptoms of knee osteoarthritis and supported physical function of knee joints.
Clinical Study 2
Turmacin® (0.5g and 1g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants.
Clinical Study 3
Compared to placebo, the Turmacin®/ curcuminoids combination significantly improves knee pain and function among people with inflammatory knee osteoarthritis.
Clinical Study 4
B-Turmactive and BY reduced self-reported, mild/moderate joint pain after 3 days and 1 week of treatment. The analgesic effect of B-Turmactive was progressive and accompanied by an objective decrease in inflammatory status.
Clinical Study 5
Turmacin® an extract of Curcuma longa containing Turmerosaccharides was found to be safe and tolerable at both the tested doses administered for the given duration of trial period in healthy adult volunteers.
Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial
Condition
Subjects with primary knee osteoarthritis
Dose
500 mg twice a day
Participants
30 subjects per group (Age: ≥ 40 years)
Duration
42 days
Evaluation
On day 21 and day 42 using WOMAC, VAS, and CGIC scales
Outcome
Turmacin® effectively managed the symptoms of knee osteoarthritis and supported physical function of knee joints
Madhu et al. Inflammopharmacology 2013, 21(2): 129-136.
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Effect of Turmacin® supplementation on joint discomfort and functional outcome among healthy participants: A randomized placebo-controlled trial
Condition
Healthy volunteers
Dose
0.5 g and 1 g
Participants
90 subjects
Duration
84 days
Evaluation
Valuation of pain at days 1, 5, 7, 28, 56, and 84 for VAS; Time to onset of pain; Range of Motion using Electrogoniometry, Joint function and force assessment using Isokinetic dynamometry
Outcome
Turmacin® (0.5g and 1g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants
Jeffrey Pradeep Raj et al, Complementary Therapies in Medicine 53 (2020) 102522
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Clinical Evidence for Turmacin® – A randomised placebo controlled study in Australia
Condition
Subjects with knee osteoarthritis, and the presence of a moderate amount of effusion-synovitis
Dose
800 mg Turmacin® plus 200 mg curcuminoids
Participants
70 subjects
Duration
12 weeks
Evaluation
Knee MRI scans and their knee pain was calculated using the VAS scale. Also, OARSI-OMERACT was used.
Outcome
Compared to placebo, the Turmacin®/ curcuminoids combination significantly improves knee pain and function among people with inflammatory knee osteoarthritis.
Wang Z et al., Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Ann Intern Med. 2020 Sep 15. doi: 10.7326/M20-0990.
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Clinical Evidence for Turmacin® – A Randomised, Parallel and Double Blind study in Spain
Condition
Mild and Moderate Knee Pain on Healthy Volunteers
Dose
New formulation of water-soluble Turmeric extracts 500 mg and insoluble curcuminoids (B-Turmactive) 19.5 mg or brewer’s yeast as a placebo for 1 week
Outcome
B-Turmactive and BY reduced self-reported, mild/moderate joint pain after 3 days and 1 week of treatment. The analgesic effect of B-Turmactive was progressive and accompanied by an objective decrease in inflammatory status,
Participants
68 subjects
Duration
1 weeks
Evaluation
Primary: WOMAC pain subscale on day 1; day 3; day 7. Visual analogue scale of 5 items derived from 24 items WOMAC scale
Secondary: Anthropometric data; Biochemistry for on-going study control; Biochemistry for on-going study control.
Lorena Calderón-Pérez et al, Journal of Medicinal Food, http://doi.org/10.1089/jmf.2020.0074
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Safety Clinical Evidence for Turmacin® – A randomised open label clinical study in healthy volunteers
Condition
Healthy subjects
Dose
1000 or 2000 mg of Turmacin® an extract of Curcuma longa
Participants
48 subjects (24 each arm)
Duration
84 days
Evaluation
Haematological, biochemical, and urinalysis parameters) were assessed at baseline, day 42 and 84 as primary endpoint. The secondary end point was change in the vital signs, electrocardiogram (ECG) from baseline on day 42 and 84
Outcome
Turmacin® an extract of Curcuma longa containing Turmerosaccharides was found to be safe and tolerable at both the tested doses (till 2g) administered for the given duration of trial period in healthy adult volunteers.
Selvi et al.Safety of NR-INF-02, an Extract of Curcuma long containing turmerosaccharides, in healthy volunteers: A Randomized, Open-label Clinical Trial. Alternative Therapies in Health and Medicine 2020 Aug 20; AT6360. Online ahead of print.
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Pre-Clinical Evidence: Effect on Inflammation and Pain Severity
Outcomes of the study
Reference: Sasikumar et al. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2017, 16, 193-202
Turmacin® reduced pain severity by 50%
in 3 hours & the effect was maintained till 24 hours
Turmacin® has multiple modes of action
Turmacin® supports joint health by maintaining equilibrium
between degradation and synthesis of cartilage matrix
Reduces production of:
- Inflammatory mediators
- Reactive oxygen species
- Aging
Increases synthesis of:
- Collagen synthesis
- TProteoglycan synthesis
- Anti-inflammatory cytokines
Health Benefit :
Helps maintain healthy joint function*
Dosage:
500 mg – 1000 mg per day
Turmacin®: Stands for the things that matter to you
Formulations possible with Turmacin®
Applications of Turmacin®
Healthy aging
Turmacin® has been clinically demonstrated effective for relieving symptoms of arthritis, making it an excellent choice for joint health products.
Sports and fitness
Turmacin® is an excellent choice for endurance products because it increases the time to onset of pain during exercise, allowing fitness enthusiasts to push harder, longer. And since it effectively eases joint pain and increases joint mobility in physically active people.
Functional food and beverages
Turmacin® has achieved self-affirmed GRAS status, so it is approved for use in functional foods and beverages. Unlike fat-soluble curcuminoid preparations, Turmacin® dissolves easily in water and stays in solution, avoiding the sediment problem.
Turmacin® + Curcuminoids = Full Spectrum Activity
Turmacin® can be used as a standalone ingredient or combined with curcuminoids to create a fullspectrum turmeric product delivering both fat and water-soluble components of the herb. This approach may be particularly appealing to consumers who are drawn to the concept of whole-herb standardized extracts.
Why choose Turmacin®?
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