Ap Bio Kalm Cold

  • Effectivity
  • Clinical Research
  • Mechanisms of Action
  • Health Claims
  • Dosage
  • Why choose AP BIO® / Kalm-Cold®?
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Discover AP-Bio® / KalmCold® Discover AP-Bio

Discover AP-Bio® / KalmCold®

AP-Bio® / KalmCold® is a fast-acting Andrographis paniculata with 7 bioactives, clinically researched to manage the symptoms of common cold at a low dose.

Effectively BK

AP-Bio® / KalmCold®works for you by effectively

lowering the symptoms of cold and flu (Immune Health)

FeverCoughEaracheHeadacheFatigueNasaldischargeExpectorationSleepdisturbanceSore throat

Cough

Cough

Earache

Earache

Headache

Headache

Sore throat

Sore throat

Fatigue

Fatigue

Fever

Fever

Sleep disturbance

Sleep disturbance

Nasal discharge

Nasal discharge

Expectoration

Expectoration

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AP-Bio® / Kalm-Cold® is backed by 3 clinical studies:

Clinical Study 1

AP-Bio® / Kalm-Cold® 200 mg and 400 mg groups showed significantly better resolution of symptoms of uncomplicated upper respiratory tract infections when compared with placebo

Clinical Study 2

AP-Bio® / Kalm-Cold® showed 2 times efficacy as compared to placebo and was well tolerated

Clinical Study 3

AP-Bio® / Kalm-Cold® supports immunity by increasing INF gamma, IL-4 coupled by increased CD4+ and absolute lymphocytes count and decreasing IL-2

Randomized double-blind placebo-controlled clinical studyof AP-Bio® / KalmCold®- Healthy-inflammatory response

Condition

Condition

Subjects with symptoms of upper read more respiratory tract infection

Participants

Participants

300 adults (Age: 18-60 years)

Dose

Dose

200 mg and 400 mg

Duration

Duration

7 days

Evaluation

Evaluation

Baseline, 6 hours, Day 2, Day 3, Day 5 and Day 7

Outcome

Outcome

AP-Bio® / KalmCold® 200 mg and 400 mg groups showed significantly better read more resolution of symptoms of uncomplicated upper respiratory tract infections when compared with placebo

Jeffrey Pradeep Raj et. al., Complementary Therapies in Medicine 73 (2023) 102934, Efficacy and safety of AP-Bio®(KalmCold®) in participants with uncomplicated upper respiratory tract viral infection (common cold) − A phase III, double-blind, parallel group, randomized placebo-controlled trial, 2023

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Randomized double-blind placebo-controlled clinical studyof AP-Bio® / KalmCold® - Healthy-inflammatory response

Condition

Condition

Subjects with symptoms of common cold

Participants

Participants

223 adults (Age: 18-60 years)

Dose

Dose

200 mg per day

Duration

Duration

5 days

Evaluation

Evaluation

Day 1, Day 3, and Day 5 (using Visual Analogue Scale)

Outcome

Outcome

AP-Bio® / KalmCold® showed 2 times read more efficacy as compared to placebo and was well tolerated

Saxena et. al., Phytomedicine 17 (2010) 178–185, A randomized double blind placebo controlled clinical evaluation of extract of Andrographis paniculata (KalmColdTM) in patients with uncomplicated upper respiratory tract infection

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Randomized double-blind placebo-controlled clinical studyof AP-Bio® / KalmCold® - Healthy-inflammatory response

Condition

Condition

Healthy volunteers

Participants

Participants

30 adults

Dose

Dose

100 mg twice a day

Duration

Duration

30 days

Evaluation

Evaluation

Screening day, day 3, day 7, day 30

Outcome

Outcome

AP-Bio® supports immunity by read more increasing INF gamma, IL-4 coupled by increased CD4+ and absolute lymphocytes count and decreasing IL-2

Rajanna et. al., Journal of Ayurveda and Integrative Medicine 12 (2021) 529e534, Immunomodulatory effects of Andrographis paniculata extract in healthy adults e An open-label study

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Reduction in common cold symptoms

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  • AP-Bio® / Kalm-Cold® showed prominent effects at day 3 and the efficacy is 1.6 times the placebo effects.
  • Minimal clinical important difference was observed at day 3.

Effect of AP-Bio® / Kalm-Cold® on Nasal mucosal weight

Graph

The objective parameters like nasal mucosal weight, number of tissue papers used showed a strong trend towards significant difference in both the AP-Bio® / Kalm-Cold® groups when compared to the placebo group.

Effect of AP-Bio® / Kalm-Cold® on Tissue counts

Graph

The objective parameters like nasal mucosal weight, number of tissue papers used showed a strong trend towards significant difference in both the AP-Bio® / Kalm-Cold® groups when compared to the placebo group.

Reduction in common cold symptoms

Graph

Overall symptoms score

Graph

AP-Bio® / Kalm-Cold® showed 2 times efficacy as compared to placebo and was well tolerated

Graph
Graph
Graph
Graph
Graph
Graph
Overall Symptoms Bk

Overall symptoms score

Overall symptoms score
Turmacin reduced pain

Outcome

Reduced symptoms 55% faster than placebo

Mechanisms of Action Inflammatory Balance

Mechanisms of Action

AP-Bio® / KalmCold® works by immuno-modulatory and anti-inflammatory balance
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AP-Bio® / KalmCold®: Sustainably making a difference at every step Sustainably Difference

AP-Bio® / KalmCold®: Sustainably making a difference at every step

AP-Bio® / KalmCold® is a renewable resource as it is made from sustainable Andrographis paniculata. The process of cultivating Andrographis paniculata for AP-Bio® / KalmCold® has always been one that keeps renewability of resources – including human – at the forefront to ensure consistent high-quality yields.

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We minimize our carbon footprint by cultivating mostly with non-fossil fuels and without machinery that uses the fossil fuels. We reuse the water used for growing the crop. During manufacturing/processing, the majority of the power utilized is from hydro and solar energy sources. All the wastes from the manufacturing facility are disposed responsibly as per statutory norms. We are an ISO14001-certified (environmental management) organization, and our manufacturing facility is surrounded by trees to provide a green belt.

We are proud of our clean label attributes – AP-Bio® / KalmCold® is USP compliant for pesticide residue and heavy metals,non-irradiated, NON-GMO project-verified, and is certified both Kosher and Halal. AP-Bio® / KalmCold® is manufactured under strict global guidelines of safety and quality control. Its manufacturer, Natural Remedies, has achieved ISO 22000, ISO 9001 and OHSAS 18001 certification from Bureau Veritas, is NSF GMP-certified, USFDA inspected.

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Health Claims*

The human clinical study on AP-Bio® / KalmCold® allows for the following health claims:

Supports immunity

Supports immunity

Positively modulates immune response

Positively modulates immune response

Improve general immune health

Improve general immune health

Helps strengthen the immune system

Helps strengthen the immune system

Helps to reduce symptoms of common cold and upper respiratory tract infections (such as sore                       throat, cough, runny nose, fatigue, plugged nose & fever)

Helps to reduce symptoms of common cold and upper respiratory tract infections (such as sore throat, cough, runny nose, fatigue, plugged nose & fever)

Helps to reduce/relieve the severity of symptoms associated with upper respiratory tract                       infections (eg. common cold and flu)

Helps to reduce/relieve the severity of symptoms associated with upper respiratory tract infections (eg. common cold and flu)

Support immune function and to relieve symptoms of mild fever, common cold and sore throat

Support immune function and to relieve symptoms of mild fever, common cold and sore throat

Supports immunity

Supports immunity

Positively modulates immune response

Positively modulates immune response

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AP Bio BK
ap-bio-Dosage Tablet

Dosage:

200mg – 400mg per day

Holixer Stands BK

AP-Bio® / KalmCold®: Stands for things that matter to you

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Formulations possible with AP-Bio® / Kalm-Cold®

Formulations possible with AP-Bio
Capsule

Tablets

Sachet

Capsules

ap-bio video to learn more

Watch the AP-Bio® / KalmCold®video to learn more.

AP-Bio® / KalmCold® - Fast acting Andrographis paniculata to support Immune health

Faster onsetof action More than800 Million dosessold worldwide 7 unique bioactivesClinically researched to work by healthy inflammatory response & immuno-stimulatory balance 3 clinical studieson immunity Low dose allowsflexibility in formulation NON-GMO project verified Sustainablesupply chain WhyChooseAP-Bio® / Kalm-Cold®?

Why choose AP-Bio® / KalmCold®?

7 unique bioactives

7 unique bioactives

Faster onset of action

Faster onset of action

Low dose allows flexibility in formulation

Low dose allows flexibility in formulation

NON-GMO project verified

NON-GMO project verified

Sustainable supply chain

Sustainable supply chain

More than 800 Million doses sold worldwide

More than 800 Million doses sold worldwide

3 clinical studies on immunity Clinically researched to work by healthy inflammatory response & immuno-stimulatory balance

3 clinical studies on immunity Clinically researched to work by healthy inflammatory response & immuno-stimulatory balance

Relevant & scientifically validated claims on stress & sleep

Relevant & scientifically validated claims on stress & sleep

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