Discover the power of
Turmerosaccharides™
- Clinical Research
- Multiple mode of Actions
- Health Claims
- Dosage
- Formulations
- Why choose Turmacin®?
Turmacin® and it’s development
Along with its rich history of use, turmeric’s scientific portfolio is also rich in evidence in its use particularly for managing inflammation and supporting joint health. Joint health is one of the top concerns among adults globally, as the fear of losing mobility to aggressively worsening osteoarthritis is common.
Read MoreTurmacin® is an innovative clinically researched ingredient that brings the joint and cartilage health benefits of turmeric to dietary supplements. Featuring water-soluble Turmerosaccharides™, our patented, bioactive polysaccharide, Turmacin® is the clean label, natural way to add joint and cartilage support functionality to your formulation.
As there is a bevy of turmeric extracts that focus on the content of standardized curcuminoids, the opportunity to develop an effective and safe extract that focuses on the power of its unique polysaccharides has proven worthy.
Traditional uses
Turmeric has a very long history of culinary, cosmetic, and medicinal use. Throughout Asia and India, there is substantial use of turmeric in traditional medical modalities to fight inflammation and pain.
Read MoreIn Ayurveda practices, turmeric is well-documented to have several useful actions for the treatment of rheumatism, sprains/swelling, and other conditions characterized by inflammation. Ayurvedic texts include dosage forms such as svarasa (juice), kalka (bolus/paste), kvatha (decoction), hima (cold infusion), phaṇṭa (hot infusion), and curna (powder).
In Indian culture, turmeric is held in high esteem beyond just for healing purposes. Hindus hold the herb sacred and it is part of a wedding tradition where the groom ties mangala sutra, a string dyed yellow from turmeric around the bride’s neck in a loving, symbolic gesture. And in South India, men and women who want to protect themselves from evil spirits will wear a turmeric rhizome piece as an amulet.
Water-soluble & oil-soluble components of turmeric
The vast majority of research on turmeric-based products has been conducted on:
- Whole turmeric powder
- Volatile oil portions of turmeric
- Isolated curcuminoid extracts (especially curcumin)
Meanwhile, over 90% of the remaining water-soluble constituents of turmeric have been neglected and rarely investigated for their own health benefits. That begs the question: what have we been throwing away?
At Natural Remedies, we were on a quest to discover these unexplored components of turmeric. After years and years of research by our team of herbalists and scientists, we discovered that turmeric also contains a special class of water-soluble polysaccharides that are potent, promising, and bioactive. We named them Turmerosaccharides™.
Turmacin® is backed by 5 clinical studies:
- Summary
- Clinical Study 1
- Clinical Study 2
- Clinical Study 3
- Clinical Study 4
- Clinical Study 5
Clinical Study 1
Turmacin® effectively managed the symptoms of knee osteoarthritis and supported physical function of knee joints.
Clinical Study 2
Turmacin® (0.5g and 1g) was efficacious when compared to placebo in increasing the pain threshold and knee ROM in healthy participants.
Clinical Study 3
Compared to placebo, the Turmacin®/ curcuminoids combination significantly improves knee pain and function among people with inflammatory knee osteoarthritis.
Clinical Study 4
B-Turmactive and BY reduced self-reported, mild/moderate joint pain after 3 days and 1 week of treatment. The analgesic effect of B-Turmactive was progressive and accompanied by an objective decrease in inflammatory status.
Clinical Study 5
Turmacin® an extract of Curcuma longa containing Turmerosaccharides™ was found to be safe and tolerable at both the tested doses administered for the given duration of trial period in healthy adult volunteers.
Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: A randomized placebo-controlled trial
Condition
Subjects with primary knee osteoarthritis
Participants
Total participants= 90 ( 30 subjects per group ) (Age: ≥40 years)
Dose
500 mg twice a day
Duration
42 days
Evaluation
On day 21 and day 42 using WOMAC, VAS, and CGIC scales
Outcome
Turmacin® effectively managed the symptoms of knee read more osteoarthritis and supported physical function of knee joints
Madhu et al. Inflammopharmacology 2013, 21(2): 129-136.
Know MoreEffect of Turmacin® supplementation on joint discomfort and functional outcome among healthy participants: A randomized placebo-controlled trial
Condition
Healthy volunteers
Participants
90 subjects
Dose
500 mg and 1000 mg
Duration
84 days
Evaluation
Evaluation of pain at days 1, 5, 7, 28, 56, and read more
Outcome
Turmacin® (500mg and 1000 mg) was efficacious read more
Jeffrey Pradeep Raj et al, Complementary Therapies in Medicine 53 (2020) 102522
Know MoreClinical Evidence for Turmacin® – A randomised placebo controlled study in Australia
Condition
Subjects with knee osteoarthritis, read more
Participants
Total participants= 70 (34 and 36 in each group)
Dose
800 mg Turmacin® plus 200 mg curcuminoids
Duration
12 weeks
Evaluation
Knee MRI scans and their knee pain was calculated read more
Outcome
Turmacin®+ curcuminoids combination read more
Ref: Wang Z et al., Effectiveness of Curcuma longa Extract for the Treatment of Symptoms and Effusion-Synovitis of Knee Osteoarthritis : A Randomized Trial. Ann Intern Med. 2020 Sep 15. doi: 10.7326/M20-0990.
Know MoreClinical Evidence for Turmacin® – A Randomised, Parallel and Double Blind study in Spain
Condition
Mild and Moderate Knee Pain on Healthy Volunteers
Participants
68 subjects
Dose
New formulation of water-soluble Turmeric extracts read more
Duration
1 weeks
Evaluation
Primary: WOMAC pain subscale on day 1; day 3; day 7. read more
Outcome
B-Turmactive and BY reduced self-reported, mild/moderate read more
Acute Effects of Turmeric Extracts on Knee Joint Pain: A Pilot, Randomized Controlled Trial, http://doi.org/10.1089/jmf.2020.0074
Safety Clinical Evidence for Turmacin® – A randomised open label clinical study in healthy volunteers
Condition
Healthy subjects
Participants
Total participants= 48
(24 each group)
Dose
1000 mg and 2000 mg of Turmacin®
Duration
84 days
Evaluation
Adverse events, Hematological, biochemical read more
Outcome
Turmacin® an extract of Curcuma longa containing read more
Selvi et al.Safety of NR-INF-02, an Extract of Curcuma long containing turmerosaccharides™, in healthy volunteers: A Randomized, Open-label Clinical Trial. Alternative Therapies in Health and Medicine 2020 Aug 20; AT6360. Online ahead of print.
Know More
Pre-Clinical Evidence: Effect on Inflammation and Pain Severity
Normal Control
MIA Control
Turmacin®
#p<0.05 compared to normal control
#p<0.05 compared to MIA control
MIA- Monosodium Iodoacetate
Reference: Sasikumar et al. Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry, 2017, 16, 193-202
Turmacin® reduced pain severity by 50% in 3 hours & the effect was maintained till 24 hours
Turmacin® has multiple modes of action
- Turmacin® reduces collagen degradation markers(L-6, IL-8, COx-2, PGE, TNE- alfa, ICAM-) in chondrocytes.
- Turmacin® reduces cartilage damage by increasing the gene expression of type II collagen.
- Turmacin® reduces NF-KB (a protein complex that plays central role in inflammation).
- Turmacin® decreases ageing of cartilage cells (mediated by H,0, a free radical generator).
Turmacin® supports joint health by maintaining equilibrium between degradation and synthesis of cartilage matrix
- Reduces production of:
- Inflammatory mediators
- Reactive oxygen
- Species Aging
- Increases synthesis of:
- TProteoglycan synthesis
- Anti-inflammatory cytokines
- Collagen synthesis
Health Claims*
The human clinical study on Turmacin® allows for the following health claims:
- USA
- ROW
Joint health
Helps to maintain healthy joint function
Supports joint mobility
Helps to reduce exercise induced joint pain
Joint health
Helps to maintain healthy joint function
Helps to maintain joint mobility
Helps to improve joint health and mobility in people with age-related joint discomfort
Helps to reduce exercise induced joint pain
Dosage:
500 mg-1000 mg per day
Turmacin®: Stands for the things that matter to you
Formulations possible with Turmacin®
Lozenges
Tablets
Shots
Candies
Creams
Capsules
Ointments
Sprays
Biscuits
Beverages
Nutri-bars
Effervescent powders
Gummies
Applications of Turmacin®
Turmacin® has achieved self-affirmed GRAS status, so it is approved for use in functional foods and beverages. Unlike fat-soluble curcuminoid preparations, Turmacin® dissolves easily in water and stays in solution, avoiding the sediment problem.
Functional food and beverages
Turmacin® has been clinically demonstrated effective for relieving symptoms of arthritis, making it an excellent choice for joint health products.
Healthy aging
Turmacin® can be used as a standalone ingredient or combined with curcuminoids to create a fullspectrum turmeric product delivering both fat and water-soluble components of the herb. This approach may be particularly appealing to consumers who are drawn to the concept of whole-herb standardized extracts.
Turmacin®+Curcuminoids = Full Spectrum Activity
Turmacin® is an excellent choice for endurance products because it increases the time to onset of pain during exercise, allowing fitness enthusiasts to push harder, longer. And since it effectively eases joint pain and increases joint mobility in physically active people.
Sports and fitness
Turmacin®: Sustainably making a difference at every step
The process of cultivating Curcuma longa for Turmacin® has always been one that keeps renewability of resources – including human – at the forefront to sustain quality yields.
We minimize our carbon footprint by cultivating mostly with non-fossil fuels and without machinery that uses the fossil fuels. We reuse the water used for growing the botanical crop. During manufacturing/processing,
Read MoreThe majority of the power utilized is from hydro and solar energy sources. All the effluents from manufacturing facility are disposed responsibly as per statutory norms. We are an ISO14001-certified (environmental management) organization, and our manufacturing facility is surrounded by trees to provide a green belt.
Turmacin® is manufactured under strict global guidelines of safety and quality control. Its manufacturer, Natural Remedies, has achieved ISO 22000, ISO 9001and OHSAS 18001 certification from Bureau Veritas, is NSF GMP-certified, USFDA inspected.
Turmacin®: Sustainably making a difference at every step
Watch the Turmacin® video to learn more.
Discover the power of Turmerosaccharides™ with Turmacin®.
Watch the Turmacin® video to learn more.
Turmacin®- Power of Turmerosaccharides® for joint health is clean label (100% Turmeric extract)
Why choose Turmacin®?
Non-staining of equipment
Wide range of formulations possible
Non-GMO Project Verified
Sustainable supply chain
100% Naturally Bioavailable
Standardized to Turmerosaccharides™ The bioactive polysaccharides
Backed by 5 human clinical studies on joint health and safety
Can be combined with curcumin and other joint health ingredients
Self affirmed GRAS (application in food and beverages)
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