Ap Bio Kalm Cold
- Clinical Research
- Mechanisms of Action
- Dosage
- Application of GutGard®
- Why Choose GutGard®?
GutGard® and it’s development
Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. Poor digestion leads to lack of energy, poor sleep, and overall malaise.
GutGard® goes beyond deglycyrrhization, as conventional DGL extracts lack bioactive flavonoids found in the root. GutGard® is extracted using a unique extraction process that retrieves the bioactive flavonoid profile. It is standardized to contain 10% total flavonoids no more than 0.5% glycyrrhizin. And the key difference between GutGard® and DGL extract is that DGL extracts typically contain negligible amounts of flavonoids – in fact, DGL is a product obtained following the removal of glycyrrhizin and is not standardized to any biologically active constituents. GutGard® is closer to nature than DGL as acids are not used in its production process, whereas DGL production involves treatment with acids/alkali.
GutGard® for daily digestive health
GutGard is a clinically tested nutraceutical ingredient that reduces gastro intestinal irritation and discomfort. GutGard is derived from the natural Glycyrrhiza glabra(liquorice) plant and contains high levels of glabridin.
GutGard® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard® by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.
GutGard® works for you by effectively
Eliminating heartburn & regurgitation along with improving general digestive health
Early satiety
Upper abdominal fullness & pain
Heartburn/regurgitation after meals
Nausea
Heartburn while lying/ standing
Loss of appetite
Pain in swallowing
Vomitting
Belching
Bloating
GutGard®: Backed by human clinical
studies for daily digestive health
- Summary
- Clinical Study 1
- Clinical Study 2
- Clinical Study 3
Clinical Study 1
GutGard® showed 88% reduction in the total symptoms score to effectively eliminate heartburn & regurgitation By day 28, 87% reduction in the frequency of heartburn and 72% reduction in the severity of heartburn was assessed
Clinical Study 2
GutGard® significantly lowers the symptoms of daily digestive health problems (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life
Clinical Study 3
48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT
Randomized double-blind, placebo-controlled clinical study in Subjects with Gastro-Esophageal Reflux (GER) Related Symptoms - Heartburn & Regurgitation
Condition
Subjects with Heartburn & Regurgitation - Gastro-Esophageal Reflux(GER) Related Symptoms
Participants
200 subjects (Age: 18-60 years)
Dose
75 mg twice a day before food
Duration
28 days
Evaluation
On day 0, 7, 14 and day 28 & 7-days post treatment for rebound effect
Outcome
GutGard® effectively eliminated the symptoms of Gastro-Esophageal Reflux (GER) (heartburn and regurgitation)
Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012, Article ID 216970, 9 pages, 2012.
Know MoreRandomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.
Condition
Subjects with functional dyspepsia
Participants
50 subjects (Age: 18-65 years)
Dose
75 mg, two times a day after food
Duration
30 days
Evaluation
On day 15 and day 30
Outcome
GutGard® effectively managed the symptoms read more of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting) GutGard® improved quality of life
Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori
Condition
Subjects with gastric load of Helicobacter pylori
Participants
107 subjects (Age: 18-45 years)
Dose
150 mg/day before breakfast
Duration
60 days
Evaluation
On day 30 and day 60, using 13C-UBT and HpSA test
Outcome
GutGard® showed 41% reduction in H. pylori load read more compared to the placebo. 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT.
Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.
Know More
GutGard® pre-clinical research
- Preclinical 1
- Preclinical 2
Objective
To determine the anti-ulcer and antioxidant potential of GutGard®
Dose
12.5, 25, and 50 mg per kg
Test
The effect of GutGard® was studied on gastric read more ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.
Evaluation
Anti-ulcer activity was evaluated by measuring the ulcer read more index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.
Outcome
GutGard® possessed anti-ulcerogenic properties read more that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.
Objective
To evaluate the gastroprokinetic effect of read more flavonoid-rich root extract of Glycyrrhiza glabra (GutGard®) and glabridin in albino Wistar rats using the phenol red meal model.
Test
Gastroprokinetic effect using Phenol red meal model
Dose
Various dose levels of GutGard® (6.25, 12.5, and 25 mg per kg)
Evaluation
The gastroprokinetic effect of flavonoid-rich root read more extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.
Outcome
Rats treated with GutGard® exhibited a read more statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard® and glabridin is comparable to domperidone, a potent prokinetic agent.
GutGard®: Mechanisms of action
Various studies have shown that GutGard® supports digestive functioning
through several mechanisms of action:
- Possess antioxidant properties (Inhibits DPPH, ABTS) and possess good ORAC
- Works against H. pylori (in vitro inhibited H. pylori protein synthesis, DNA gyrase and dihydrofolate reductase)
- Acts as a prokinetic agent; modulates gut motility
- Reduces inflammatory mediators like PGE2, TXB2, LTB4 NO, IL-1beta and IL-6
- Acts as a gastroprotective
Dosage:
150 mg per day
GutGard®: Stands for things that matter to you
Formulations possible with GutGard®
Sachets
Tablets
Chews
Beverages
Shots
Capsules
Oral Strips
Applications of GutGard®
- GutGard® with Probiotics
- Gutgard® Can Be Combined With Digestive Enzymes
Probiotic count (cfu/ml)
Log Values
PB-Probiotic drink
GGPB-GutGard® + Probiotic drink
GutGard® works synergistically with Digestive Enzymes
GutGard® does not inhibit digestive enzymes, viz.Da-amylase, a-glucosidase, phytase, and xylanase
GutGard® was found to be safe when tested with these digestive enzymes
- GutGard® added to probiotic drink
- Probiotic count remained at the acceptable level
- Indicates GutGard® is compatible with tested probiotic drink
GutGard® tested against some common probiotic bacteria
High MIC of GutGard® indicates the reasonable safety against these probiotic bacteria
Water activity (aW) of GutGard® is less than 0.2
Low water activity of GutGard® makes it suitable for probiotic powders
Good compatibility with probiotic bacteria makes it suitable for probiotic drinks
Watch the GutGard® video to learn more.
GutGard® - Flavonoid-rich bioactive for daily digestive health
Why choose GutGard®?
Wide range of delivery applications like chews, gummies, beverages and powders are possible.
Clinically studied to support management of Helicobacter pylori
<0.5% glycyrrhizin ensures higher safety
Low dose allows for flexibility in formulations
Works symbiotically with probiotics and digestive enzymes
Soft extraction process to retain and enrich the goodness of flavanoids
Clinically studied for alleviating symptoms of daily gut health issues
High flavonoids (10% w/w) by HPLC and >50 different flavonoids identified by LC-MS
Clinically studied for relieving gastro-esophageal reflux related symptoms like heartburn & regurgitation
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