GutGard® and
it’s development

Digestive disturbances are affecting more individuals than ever, largely due to stress and dietary habits (eg: nutritionally lacking, as well as eating quickly, on the run). These factors combine to create a host of issues such as gas and bloating, acid reflux/heartburn, stomach griping, flatulence, diarrhea, cramps, and constipation. And, poor digestion leads to lack of energy, poor sleep, and overall malaise. Upper digestive ailments are also often caused by a bacterial infection, chiefly, Helicobacter pylori.

GutGard® for digestive health

GutGard® is an innovative, clinically researched, flavonoid-rich bioactive for gut health, derived from Glycyrrhiza glabra. GutGard® is standardized to >3.5% glabridin and >10% total flavonoids with glycyrrhizin level to be made <0.5% .

GutGard® is the only of its class to offer the advantage of the cache of flavonoids found in licorice. More than 50 flavonoids including isoflavans (glabridin), Isoflavones (example: licoflavone A), Isoflavanones (example: glabrol), chalcones (example: isoliquiritigenin), etc, have been identified in GutGard®by using liquid chromatography-mass spectrometry. Batch to batch consistency of the flavonoid profile is monitored with the help of high-performance liquid chromatography.

Traditional uses

Licorice has a long, rich use in cultures worldwide; it was even found in the tomb of King Tutankhamun. The dried root of licorice has been used by not only the Egyptians but throughout the populations and cultures of Asia and the Mediterranean regions. The Romans relied on it for numerous ailments. Licorice is recorded in the pharmacopoeias of nations throughout the world.

In the first century AD, the Greek physician Dioscorides used licorice to treat people with stomach and intestinal ulcers (it is known now that many ulcers are caused by Helicobacter pylori).

Licorice was revered by the ancient Egyptians who used it to make tonics that were placed in the canopic jars to accompany them into the afterlife. It is also said that legendary generals Julius Caesar, Alexander the Great, and Napoleon Bonaparte used licorice. In the Eurasian steppe, the Scythian tribes relied on licorice to survive when water was scarce.

GutGard®: Backed by human clinical studies for holistic gut health

Clinical study 1

  • GutGard® effectively managed the symptoms of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)
  • GutGard® improved quality of life

Clinical study 2

  • 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT

Clinical Study 1

  • GutGard® effectively managed the symptoms of Functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)
  • GutGard® improved quality of life

Clinical Study 2

  • GutGard® showed 41% reduction in H. pylori load compared to placebo
  • 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT

Randomized double-blind, placebo-controlled clinical study in subjects with Functional dyspepsia.

Condition

Subjects with functional dyspepsia

Dose

75 mg, two times a day after food

Participants

50 subjects (Age: 18-65 years)

Duration

30 days

Evaluation

On day 15 and day 30

Outcome

GutGard® effectively managed the symptoms of functional dyspepsia (upper abdominal fullness, belching, regurgitation, upper abdominal pain, nausea, bloating, and vomiting)

GutGard® improved quality of life

Raveendra et al. Evidence-Based Complementary and Alternative Medicine 2012,Article ID 216970, 9 pages, 2012.

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Effects of GutGard® on Functional Dyspepsia

Randomized double-blind, placebo-controlled clinical study in subjects with H. pylori

Condition

Subjects with gastric load of Helicobacter pylori

Dose

150 mg/day before breakfast

Participants

107 subjects (Age: 18-45 years)

Duration

60 days

Evaluation

On day 30 and day 60, using 13C-UBT and HpSA test

Outcome

GutGard® showed 41% reduction in H. pylori load compared to the placebo. 48% of the population in the GutGard® group were relieved from H. pylori as assessed by 13C-UBT.

Puram et al. Evidence-Based Complementary and Alternative 2013, Article ID 263805, 8 pages, 2013.

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Effects of GutGard® on H. pylori

GutGard® pre-clinical research

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Objective

To determine the anti-ulcer and antioxidant potential of GutGard®

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Evaluation

Anti-ulcer activity was evaluated by measuring the ulcer index, gastric content, total acidity, and pH of gastric fluid. The antioxidant activity was evaluated by the oxygen radical absorbance capacity (ORAC) assay. GutGard® exhibited potent antioxidant activity with high hydrophilic and lipophilic ORAC value.

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Test

The effect of GutGard® was studied on gastric ulcers in pylorus ligation-, cold-restraint stress- and indomethacin-induced gastric mucosal injury in rats.

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Outcome

GutGard® possessed anti-ulcerogenic properties that might be afforded via a cytoprotective mechanism by virtue of its antioxidant properties. These results supported the ethnomedical uses of licorice in the treatment of gastric ulcer.

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Dosage

12.5, 25, and 50 mg per kg

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Objective

To evaluate the gastroprokinetic effect of flavonoid-rich root extract of Glycyrrhiza glabra (GutGard®) and glabridin in albino Wistar rats using the phenol red meal model.

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Test

Gastroprokinetic effect using Phenol red meal model

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Evaluation

The gastroprokinetic effect of flavonoid-rich root extract of Glycyrrhiza glabra, the effect of glabridin on gastric emptying and gastrointestinal transit were also explored.

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Dosage

Various dose levels of GutGard® (6.25, 12.5, and 25 mg per kg)

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Outcome

Rats treated with GutGard® exhibited a statistically significant increase in percentage gastric emptying as well as gastrointestinal transit over the normal control group. Gastric emptying of GutGard® and glabridin is comparable to domperidone, a potent prokinetic agent.

GutGard®: Mechanism of action

Works against H. pylori (in vitro inhibited H. pylori protein synthesis, DNA gyrase and dihydrofolate reductase)

Health benefits

Dosage*

150 mg per day

Applications of GutGard®

Probiotic count (cfu/ml)

  • GutGard® added to probiotic drink (Lactobacillus acidophilus)
  • This indicates GutGard® is compatible with tested probiotic drink
  • Probiotic count remained at the acceptable level

GutGard® can be combined with the Digestive Enzymes

GutGard®: Sustainably making a difference
at every step

The process of cultivating Glycyrrhiza glabra for GutGard® has always been one that keeps the renewability of resources – including human – at the forefront to sustain quality yields. We minimize our carbon footprint by cultivating mostly with non-fossil fuels and without machinery that uses fossil fuels. We reuse the water used for growing the botanical crop. During manufacturing/processing, most of the power utilized is from hydro and solar energy sources. All the effluents from the manufacturing facility are disposed of responsibly as per statutory norms. We are an ISO14001-certified (environmental management) organization, and our manufacturing facility is surrounded by trees to provide a green belt. Further, for today’s consumer whose standards are higher than ever – requiring that the companies they support are those that support the earth and ensure safety and transparency, GutGard® is attractive. Consumers will appreciate its clean label attributes – USP compliant for pesticide residue and heavy metals, non-irradiated, NON-GMO Project-verified, and is certified both Kosher and Halal. GutGard® is manufactured under strict global guidelines of safety and quality control. Its manufacturer, Natural Remedies, has achieved ISO 22000, ISO 9001and OHSAS 18001 certification from Bureau Veritas, is NSF GMP-certified, USFDA inspected.

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